As long as the LTO storage can be referenced by a UNC path, Laserfiche can use it as a storage location for content. My understanding is that LTO storage is slow; keep in mind that the slowdown your storage causes will appear as slowdown in the Laserfiche Client when opening entries with content stored in that location. If you absolutely need to use LTO storage, consider setting up a secondary volume for that purpose, and only moving items there that are infrequently referenced. More information about setting up a volume can be found in the Laserfiche Administration help files.