Hi Jeff, in addition to what Xiuhong Xiang asked about, they might also be running to an IIS "cold start" where the app pool only starts up once it receives a request and terminates after 20 minutes of no activity. 

I have a PowerShell script that changes IIS settings so that Laserfiche app pools start up when the IIS server starts and stay running instead of shutting down after an idle timeout. Worth giving a spin. I run this on every web server on every deployment I do. Note that it requires a server restart to take full effect.

#From: http://www.herlitz.nu/2017/11/07/enable-IIS-preloadEnabled-and-AlwaysRunning-using-PowerShell/
### Enable if required
#Import-Module ServerManager
#Add-WindowsFeature Web-Scripting-Tools

Write-Host "*** Start IIS Settings Optimization Script ***"
Import-Module WebAdministration

#Set the site name
$siteName = "Default Web Site"

#Fetch the site
$site = Get-Website -Name $siteName
if (!$site)
{
    Write-Host "Site $siteName could not be found, exiting!" -ForegroundColor Yellow
    Break
}

#Fetch the application pools
$appPools = Get-ChildItem "IIS:\AppPools\"

#Fetch the site collection (web apps under the site)
$appCollection = Get-ChildItem "IIS:\Sites\$siteName" | Where-Object {$_.NodeType -eq 'application'}

#Declare apps to preload
$appsToPreload = New-Object System.Collections.ArrayList(,('AuditTrail','FederatedSearch','Forms','Laserfiche','LFCMIS','LDPS','LFDS','LFDSSTS','Mobile','WebLink','Workflow'))
$appsToPreloadUndetected = $appsToPreload.Clone()


#Useful resource on working with IIS recycle times in PowerShell: 
#https://www.habaneroconsulting.com/stories/insights/2013/set-the-specific-times-to-recycle-an-application-pool-with-powershell

#Set to desired daily recycle time
$recycleTimes = @("04:00")

Write-Host "***************************************************"
Write-Host "* Update all IIS AppPools to:                     *"
Write-Host "* -Disable idle timeouts                          *"
Write-Host "* -Schedule consistent app pool recycling time(s) *"
Write-Host "* -Set Start Mode to AlwaysRunning                *"
Write-Host "***************************************************"
Write-Host "`n" 

foreach ($appPool in $appPools) {
    if ($appPool.processModel.idletimeout -ne '0')
    {
        $appPool | Set-ItemProperty  -Name processModel -value @{idletimeout='0'}
        Write-Host "$($appPool.Name) idle timeout disabled" -ForegroundColor Green
    }`
    else 
    {
        Write-Host "$($appPool.Name) already has idle timeout disabled" -ForegroundColor Yellow
    }
    
    #Clear existing recycle schedule and add specified schedule
    #Easier than trying to check all the collection values and ensures setting is correct at the end
    $appPool | Clear-ItemProperty -Name Recycling.periodicRestart.schedule
    foreach ($recycleTime in $recycleTimes) {
        $appPool | Set-ItemProperty -Name Recycling.periodicRestart.schedule -Value @{value=$recycleTime}
        Write-Host "$($appPool.Name) added recycle time at $recycleTime" -ForegroundColor Green
    }

    if ($appPool.Recycling.periodicRestart.time -ne '00:00:00') 
    {
        $appPool | Set-ItemProperty -Name Recycling.periodicRestart -Value @{time='00:00:00'}
        Write-Host "$($appPool.Name) revolving recycling disabled" -ForegroundColor Green
    }`
    else {
        Write-Host "$($appPool.Name) already has revolving recycling disabled" -ForegroundColor Yellow
    }

    if ($appPool.startMode -ne "AlwaysRunning")
    {
        Write-Host "$($appPool.Name) startMode is set to $($appPool.startMode), activating AlwaysRunning"
        
        $appPool | Set-ItemProperty -Name "startMode" -Value "AlwaysRunning"

        Write-Host "$($appPool.Name) startMode is now set to $($appPool.startMode)" -ForegroundColor Green
    } `
    else 
    {
        Write-Host "$($appPool.Name) startMode was already set to $($appPool.startMode) " -ForegroundColor Yellow
    }
    Write-Host "`n"
}
Write-Host "`n"


#Ensure Application Initialization is available
$webAppInit = Get-WindowsFeature -Name "Web-AppInit"

if (!$webAppInit.Installed) #
{
    Write-Host "$($webAppInit.DisplayName) not present, installing"
    Install-WindowsFeature $webAppInit -ErrorAction Stop
    Write-Host "`nInstalled $($webAppInit.DisplayName)`n" -ForegroundColor Green
} `
else 
{
    Write-Host "$($webAppInit.DisplayName) was already installed" -ForegroundColor Yellow
}

Write-Host "**************************************************"
Write-Host "* Activate preloadEnabled on Laserfiche web apps *"
Write-Host "* and the IIS Site instance                      *"
Write-Host "**************************************************"
Write-Host "`n"

#Enable preloadEnabled on the IIS Site instance
if (!(Get-ItemProperty "IIS:\Sites\$siteName" -Name applicationDefaults.preloadEnabled).Value) 
{
    Write-Host "$siteName preloadEnabled is inactive, activating"
    
    Set-ItemProperty "IIS:\Sites\$siteName" -Name applicationDefaults.preloadEnabled -Value True
    
    Write-Host "$siteName preloadEnabled is now set to $((Get-ItemProperty "IIS:\Sites\$siteName" -Name applicationDefaults.preloadEnabled).Value)" -ForegroundColor Green
} `
else
{
    Write-Host "$siteName preloadEnabled already active" -ForegroundColor Yellow
}

#Enable preloadEnabled on Laserfiche web apps
foreach ($app in $appCollection) {
    $appName = $app.Name  
    if (!($app.preloadEnabled)) 
    {
        $preloadFlag = $false
        foreach ($appToPreload in $appsToPreload) {
            if ($app.Name -eq $appToPreload) {

                Write-Host "$appName is in preload list and preloadEnabled is inactive, activating"

                Set-ItemProperty "IIS:\Sites\$siteName\$appName" -Name preloadEnabled -Value $true

                Write-Host "  preloadEnabled is now set to $((Get-ItemProperty "IIS:\Sites\$siteName\$appName" -Name preloadEnabled).Value)" -ForegroundColor Green

                $appsToPreloadUndetected.Remove($appName)

                $preloadFlag = $true
            }
        }
        if ($preloadFlag -eq $false) {
            Write-Host "$appName is not on preload list"
        }
    } `
    else
    {
        $appsToPreloadUndetected.Remove($appName)
        Write-Host "$appName has preloadEnabled already active" -ForegroundColor Yellow
    } 
}

if ($appsToPreloadUndetected.count -gt 0) {
    $appsToPreloadUndetected = $appsToPreloadUndetected -join "`n"
    Write-Host "The following apps on the preload list were not detected in IIS:`n$appsToPreloadUndetected"
}
Write-Host "`n"
Write-Host "***********************************************" -ForegroundColor Green
Write-Host "* IIS Optimization Script Complete            *" -ForegroundColor Green
Write-Host "* Please restart for settings to take effect! *" -ForegroundColor Green
Write-Host "***********************************************" -ForegroundColor Green