This issue you are running into is that the LfColor.FromRgb() takes either 3 integer inputs (R,G,B) or it takes a single integer input (hex value of RGB converted to integer).  Your code is providing a String object.  The program is then trying to convert the string to an integer.  Since your string of "225,225,128" can be converted to and integer of 225225128, that is what you are passing.  If your input string had been "225, 225, 128", then the code would have thrown an error since this cannot be converted to an integer.  If you want to pass the color as a single string with 3 integers divided by comma, then you need to split the string into the 3 sperate parts.  Try something like this

                    Dim sRGB() As String = FileOperations.Anno.FillColor.Split(",")
                    Dim iR, iG, iB As Integer
                    If Integer.TryParse(sRGB(0), iR) Then
                        If Integer.TryParse(sRGB(1), iG) Then
                            If Integer.TryParse(sRGB(2), iB) Then
                                Anno.FillColor = Laserfiche.RepositoryAccess.Common.LfColor.FromRgb(iR, iG, iB)
                            End If
                        End If
                    End If

Otherwise, you can convert your 3 RGB integers to a single integer by something like this

    Private Function RGBtoInteger(ByVal iR As Integer, ByVal iG As Integer, ByVal iB As Integer) As Integer
        Dim iReturn As Integer
        Try
            Dim hexR As String = Hex(iR)
            Dim hexG As String = Hex(iG)
            Dim hexB As String = Hex(iB)
            iReturn = CInt("&H" & hexR & hexG & hexB)
        Catch ex As Exception

        End Try
        Return iReturn
    End Function