Our organization has only implemented the Web Client for our staff (by plan).  However, there are some functions that cannot be done or changed in the Web Client, and one that comes up a lot is that staff would like to change their default email attachment settings to default to attachments staying within the email when saving to the repository.  I have done this on mine, as I have the Desktop Client on my computer being the Records Coordinator.  We are on 10.2, but I have also checked in 10.4, which we currently have in our test environment, and it is still not an option there.