Tanya, thank you for the suggestion on using Workflow.  In our case, we are dealing with Signatures being applied to the PDF.  Are you aware of any method that a metadata field action could be used to trigger the insertion of a signature on the PDF?  They'd have to have a set of the PDF signatures somehow available on the Server to pull from.  Any thoughts on this?

The tricky element here is the automatic insertion of the signature. Automated signature capabilities are available with DocuSign through Web Access, Topaz signatures through Forms (configuration details here), and the Sign Document activity that applies a digital signing certificate via Workflow (more details here). Automated PDF capabilities are available in Workflow with the PDF Metadata activity, details here. However, I don’t know enough about Adobe signatures to say whether manipulating a particular PDF metadata item can insert a particular signature. Generally any automation regarding Adobe signatures involves retrieving information (through the Verify Signatures activity) rather than adding information, especially due to the sensitive nature of signatures.